Principal Clinical Database Programmer - eCOA

Role overview Design and maintain electronic Clinical Outcome Assessment (eCOA) systems used to collect trial data from participants, caregivers and clinicians. Translate study protocols and assessment requirements into validated digital questionnaires and workflows, coordinating with study teams and supporting connections to electronic data capture systems across multiple projects.

Responsibilities - Configure questionnaires, schedules, screens, field rules, branching, reminders, notifications and study settings in an approved eCOA platform. - Check configurations against specifications, prepare review materials and support user acceptance testing, issue resolution and deployment readiness. - Coordinate approved updates, translations and amendments while maintaining consistency with related data capture configurations and preserving traceability. - Work with study functions, sponsors and vendors to resolve design questions, report progress, surface risks and support timelines. - Maintain specifications, test evidence, version records and other controlled study documentation for inspection readiness. - Contribute to reusable standards and process improvements, advise project teams, and provide guidance or training to other designers as needed.

Requirements - Bachelor’s degree in life sciences, computer science, health informatics, clinical research or a related field. - Fluent written and spoken English, with strong communication and presentation skills. - Demonstrated experience with eCOA, ePRO or electronic diary solutions and clinical research in a CRO or pharmaceutical setting. - Ability to interpret protocols, assessment schedules and questionnaires and translate them into workable system designs. - Knowledge of eCOA workflows, testing, defect handling, change control, validated systems and applicable clinical research procedures and regulations. - Strong collaboration and problem-solving skills, including the ability to support global teams and manage multiple projects independently.

Nice to have - Hands-on experience with an eCOA study design platform and familiarity with EDC systems, particularly their configuration dependencies and data flows. - Experience supporting global studies, sponsor discussions, user acceptance testing and technical quality control.

Benefits and work setup - Fully home-based role open to candidates across the UK.